The full therapeutic effect develops over several days of regular use of the drug. Salmeterol effect lasts for 12 hours. This is especially true for patients with symptoms of nocturnal asthma, COPD and chronic bronchitis, as well as to prevent asthma attacks caused by exercise.
Salmeterol acts locally in the lung; durabolin injection side effects its plasma concentration does not reach therapeutic values. Available data on the pharmacokinetics of salmeterol are limited due to the fact that the definition of salmeterol in plasma is technically difficult; salmeterol concentration in plasma after dose inhalation Serevent very low (maximum concentration of 200 pg / ml or less). Excreted in the bile from the gastrointestinal tract mainly in the form of the hydroxylated metabolite.
Indications for use
Serevent used in adults and children in need for regular use of bronchodilators, as well as to prevent nocturnal symptoms and / or daytime symptoms induced reversible airway obstruction (e.g., before exercise or inevitable contact with the allergen), comprising co therapy. Adults :
- Reversible airflow obstruction at
- chronic bronchitis.
- Chronic obstructive pulmonary disease durabolin injection side effects
Children over 4 years:
- Reversible airway obstruction in asthma,
- prevention of bronchospasm.
: Hypersensitivity to salmeterol or any other component of the formulation.
Effect ß 2 agonists on the cardiovascular system can cause increased blood pressure and increased heart rate, sometimes noted when taking all sympathomimetic drugs, especially at the maximum therapeutic dose. In this regard, patients with diseases of the cardiovascular system (eg, arrhythmias, ischemic heart disease (angina III-IV functional class, acute myocardial infarction), uncontrolled hypertension), hypoxia of different genesis, pheochromocytoma Serevent should be used with caution.
Short-term decline potassium concentration in blood plasma can occur while taking all sympathomimetic drugs maximum therapeutic dose. Therefore Serevent should be used with caution in patients who have a predisposition to low potassium concentration in the blood plasma. Serevent should not be used in patients with severe deterioration or exacerbation of bronchial asthma. The use in children under the age of 4 years, there is currently insufficient data on the use of inhaled bronchodilators in children younger than 4 years. Pregnancy and lactation Serevent is not recommended during pregnancy and lactation unless the expected benefit to the mother outweighs the potential risk to the fetus or child.
Dosing and Administration
The drug is used only in the form of inhalations.
Should be used regularly to achieve optimal durabolin injection side effects therapeutic effect Serevent. The duration of treatment determined by the doctor. For patients who can not properly use the inhaler, it is necessary to use a spacer.Adults : Treatment of asthma, COPD and chronic bronchitis Recommended dosage: 2 inhalations (2 x 25 micrograms salmeterol), 2 times a day. Length of prevention of bronchospasm provoked by exercise recommended dose is 2 inhalations (2 x 25 micrograms of salmeterol) for 30-60 minutes before exercise. The maximum dose (to achieve the effect with more severe airway obstruction in asthmatic patients): 4 inhalations (4 x 25 micrograms salmeterol), 2 times a day. Children older than 4 years : Recommended dosage: 2 inhalations (2 x 25 micrograms salmeterol), 2 times a day.
Special patient groups
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There is no need to adjust the dose in elderly durabolin injection side effects patients and in patients with impaired renal function. how much to inject for weight loss
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