Reduced renal function: Serdolekt can be used in conventional dosages in patients with renal insufficiency. Hemodialysis not affect the pharmacokinetics of the drug.
Reduced hepatic function: The durabolin injection slower build-up and dosing lower doses should be used in patients with mild to moderate hepatic impairment.
Reappointment Serdolekta after interruption of treatment: If after stopping Serdolekta passed less than a week, then a gradual increase in dosage is not necessary (you can assign the same dosage). In other cases it is necessary to increase the dosage gradually until an optimal titration method, thus it is necessary to conduct a study of ECG prior to titration.
Transition from receiving other antipsychotics: Serdolektom Treatment may start with the recommended dose of a gradual build-up with the termination of the reception of another oral antipsychotic used. For patients being treated with neuroleptics, depot, Serdolekt appointed instead of the next depot injection.
Observed the following side effects (in order of decreasing frequency): rhinitis and breathing difficulties nose, reducing the volume of ejaculate, dizziness, dry mouth, postural hypotension, weight gain, peripheral edema, dizziness, paresthesia, prolongation of durabolin injection interval, leucocyturia and hematuria, hyperglycemia ., syncope, seizure disorders, movement disorders, including tardive dyskinesia, paroxysmal ventricular tachycardia (type «torsade de pointes»)
Extrapyramidal symptoms in patients receiving sertindole occur with the same frequency as with placebo.
neuroleptic malignant syndrome – very rare .
Some side effects such as postural hypotension, are transient and occur at the beginning of therapy.
Drowsiness, slurred speech, tachycardia, decreased blood pressure and a transient increase in the QT interval. Perhaps the development of paroxysmal ventricular tachycardia (type «of torsade de pointes»), especially in cases of sertindole in conjunction with drugs capable of causing this kind of side effects. Treatment. In case of overdose should stop the drug immediately, steps must be taken to maintain the airway and adequate oxygenation. There should be started immediately and ECG monitoring key physical indicators. In cases increase QT monitoring ECG interval is performed before the normalization of this index, in this case must take into account the half-life of sertindole (from 2 to 4 days). It is necessary to establish an intravenous catheter, to appoint a gastric lavage, activated charcoal and laxatives.No specific antidote and the drug is not It can be removed by dialysis. Therefore, supportive treatment should be instituted. Correction reduce blood pressure and vascular manifestations of collapse is performed using intravenous solutions. If the use of sympathomimetics, the adrenaline or dopamine should be used with caution, because the stimulation of β-adrenergic receptors with intrinsic sertindole antagonistic effect on the α 1 adrenergic receptors can lead durabolin injection to a marked reduction in blood pressure. If antiarrhythmics used, it should be borne in mind that these drugs, as quinidine, disopyramide, procainamide can potentially increase the QT interval. In case of severe extrapyramidal disorders should be assigned anticholinergics. The patient should be under constant medical supervision until complete recovery.