Durabolin price cardioselective beta 1-blocker. It has antihypertensive, antianginal, antiarrhythmic effect. It has no membranostimuliruyuschego action and has no intrinsic sympathomimetic activity. Reducing catecholamine stimulating effect on the heart, leads to a decrease in heart rate, force of myocardial contractions, cardiac output. Reduces high blood pressure at rest, exertion and stress. In the early days of treatment increases the round, in the future, long-term use, it is normal or even reduced. By reducing myocardial oxygen demand (slowing of heart rate and decreased contractility), reduces the number and severity of angina attacks and increase exercise tolerance. If supraventricular tachycardia, atrial fibrillation, sinus tachycardia with functional heart disease and hyperthyroidism slows heart rate, and may even lead to the restoration of sinus rhythm. Antiarrhythmic effect is due to the suppression of automaticity of the heart (including in the pathological focus) and slowing AV conduction. It prevents the development of migraine. To a lesser degree than the non-selective beta-blockers affect the release of insulin, and carbohydrate metabolism, masking the symptoms of hypoglycemia in diabetic patients, increases in blood levels of triglycerides, reduces the content of free fatty acids and high-density lipoproteins.
After oral metoprolol almost completely absorbed. The maximum plasma concentration is reached in 1.5-2 hours. The bioavailability increased with increased food intake and during the course of treatment. Connection with the plasma protein-10%.
Metoprolol is extensively metabolized in the liver to inactive metabolites. The half-life from the blood plasma is about 3.5 hours is derived mainly kidneys, about 3% -. Intact, the rest – in the form of metabolites. This decrease in kidney function causes a reduction of elimination of metabolites and almost no effect on the excretion of active drug.
Bioavailability is increased in liver cirrhosis.
Penetrates through the durabolin price placenta, the blood-brain barrier.
- Arterial hypertension
- Prevention of angina attacks
- Myocardial infarction (secondary prevention)
- Irregular heartbeat: supraventricular arrhythmias (tachycardia, atrial flutter, atrial fibrillation), ventricular arrhythmias (ventricular premature beats, ventricular tachycardia)
Hypersensitivity to metoprolol or other components of the drug, chronic obstructive pulmonary disease, heart failure decompensation, cardiogenic shock, atrioventricular block II-III degree, Prinzmetal angina, sick sinus syndrome, sinoatrial block, bradycardia, severe forms of Raynaud’s syndrome , obliterating peripheral vascular disease, untreated pheochromocytoma, hypotension, diabetes type I diabetes, depression, pregnancy, lactation.
Treatment should be carried Serdolom starting with a low dose with a gradual increase in the dose for 1 to 2 weeks, the drug must be carried out in one and the same time.
When hypertension effect of treatment after 2-5 days of stable therapeutic effect through 1-2 months.
it is unacceptable abrupt discontinuation of the drug, as it may lead to severe cardiac arrhythmias, myocardial infarction, sudden death. Treatment should be stopped gradually, reducing the dose for at least 10 days. Patients with coronary artery disease have at this time to be under close medical supervision
in case of severe bradycardia (heart rate less than 50-55 ppm) Serdola dose should be reduced.
When I degree atrioventricular block drug is prescribed with caution, taking into account to provide them with Dromotropic.
In the case of Prinzmetal angina beta-blockers may increase the number and duration of attacks.
patients with peripheral arterial disease (disease or Raynaud’s syndrome, arteritis, chronic obliterating lower limb arteriopathy) appointment of beta-blockers can lead to an exacerbation of these diseases, so the drug should be used with caution and with the simultaneous appointment of alpha-blockers.
Application in the treatment of hypertension caused by pheochromocytoma, requires constant control of blood pressure durabolin price.
In bronchial asthma and other chronic obstructive pulmonary disease, the drug should be used with caution.
In elderly patients treatment should be started with low doses and administered under constant medical supervision. It is recommended to monitor renal function.
Patients with diabetes should monitor blood sugar.
When you receive Serdola patients with psoriasis may increase the disease.
In patients predisposed to severe anaphylactic reaction, whatever their origin, particularly after the appointment of yodkontrastnyh drugs or during desensitizing treatment, use of beta-blockers can exacerbate allergic reactions and the absence of the effect of treatment with adrenaline at usual doses.
in the case of general anesthesia beta-blockers lead to a decrease in reflex tachycardia and increase the risk of hypotension. The anesthetist should be advised of the patient receiving beta-blockers. Thus in patients with coronary insufficiency preferably continued treatment prior to surgery because of the risks associated with the abolition of the drug. When general anesthesia should be chosen means having the least negative inotropic effect.
In the case of the kidney failure requires periodic monitoring of heart rate. Note that in the case of hyperthyroidism beta-blockers may mask the syndrome of hypoglycemia.
Patients who use contact lenses should bear in mind that during treatment with beta-blockers may reduce the production of tear fluid.
The drug may produce a positive reaction in doping control. Pregnancy and lactation : The drug is prescribed only under strict indications in connection with the possible development of the newborn bradycardia, hypotension, hypoglycemia, respiratory paralysis. Drug treatment must be interrupted for 48-72 hours before delivery. Careful medical supervision of infants in the first 3-5 days of life. No teratogenic effect of the drug was observed. The drug passes into breast milk, durabolin price so breastfeeding is incompatible with taking this medication. Running low dose t3 clen cycle trying to lose bodyfat isn’t a real hot idea imo. injectable testosterone for sale geneza pharmaceuticals for sale anavar for sale usa