Interaction with other medicinal products is not durabolin side effects recommended combinations combined use of amiodarone may result in disruption of the heart rhythm. Combinations requiring caution when using combined use of calcium channel blockers (including bepridil, diltiazem, verapamil, nifedipine), cardiac glycosides, reserpine , nitrate, clonidine, antiarrhythmics may increase the severity of bradycardia, lead to inhibition of conduction, hypotension. In these cases, treatment is carried out under medical supervision with monitoring of the electrocardiogram, particularly in elderly patients and at the beginning of treatment. Means for inhalation anesthesia during treatment with metoprolol may depress myocardial function and provoke the development of arterial hypotension. Baclofen enhances the antihypertensive effect of metoprolol. Necessary to control blood pressure, and possibly a dose adjustment of metoprolol.
Cimetidine increases the plasma concentration of the drug. The use of this combination requires the implementation of medical surveillance; if necessary, the dose of metoprolol durabolin side effects should be reduced at the time of cimetidine treatment and increased after its cancellation. Antacids (derivatives of aluminum, magnesium, calcium) reduce the absorption of metoprolol, so the time between receiving metoprolol and antacids should be at least two hours. Prior to radiological studies with iodinated contrast treatment with metoprolol should be discontinued in advance. Where metoprolol is absolutely necessary and can not be undone, you must assign the appropriate treatment. Combinations to be considered non-steroidal anti-inflammatory drugs, estrogens, beta adrenostimulyatorov, theophylline, cocaine weaken hypotensive effect of the drug. Concomitant use with imipraminovymi antidepressant (tricyclic) means and antipsychotic drugs increases the risk of severe hypotension and orthostatic hypotension. Glucocorticoids and tetrakozaktid reduce the antihypertensive effect of the drug. Phenobarbital and rifampicin reduce the concentration of metoprolol in the blood plasma, thereby reducing the effect of its application.
Overdosing Symptoms : nausea, vomiting, cyanosis, decreased blood pressure, sinus bradycardia, AV block, heart failure, cardiogenic shock, bronchospasm, loss of consciousness, coma. Treatment : In case of severe hypotension, bradycardia, heart failure – I / O, with durabolin side effects the interval 2-5 min, beta-adrenostimulyatorov to achieve the desired effect. In the absence of beta-agonists – in / 0.5-2 mg atropine sulfate.In the absence of a positive effect – the introduction of dopamine, dobutamine or norepinephrine. Further possible appointment of glucagon (1-10 mg). You may need to install the pacemaker. If bronchospasm – intravenous beta 2 -adrenomimetikov. When ventricular arrhythmia – lidocaine (IA class of drugs are not used). In convulsions – intravenous diazepam.